Nowadays the rise of Additive Manufacturing technologies, for components production in several industrial fields where high strength, stiffness and lightness are key structural requirements, is a matter of fact. However, despite the consolidation of AM as a productive method, design approaches for components are often still outdated and unable to fully benefit from potential of AM. To unlock the AM maximum potential, new design processes need to be adopted exploiting proper optimisation processes, such as the Generative Design (GD). It enables the identification of the best conceptual design for a component according to acting loads and user defined structural requirements. The aviation field turns out to be one the most benefiting from innovative design and production processes to seek lightness and high mechanical performance for components. Thus, this research introduces an innovative design for an UAV’s Vertical Tail (VT) combining the potential of Generative Design for Designed-for-Additive Manufacturing (DfAM) components with the use of lightweight high-strength technopolymers for production. An iterative process is outlined, in which the GD technique is used to define the starting conceptual design for a multi-component structure. The resulting design achieves a mass reduction of up to 73% compared to a metallic configuration, and up to 44% compared to a similar composite configuration.